Bruce Lab
We are a research laboratory studying RNA viruses, within the Department of Microbiology and Molecular Genetics (MMG) and the Translational Global Infectious Disease Research (TGIR) COBRE at the University of Vermont.
Research Interests
We are focused on studying questions at the intersection of virology and cell biology, with a particular focus on the late stages of viral assembly and replication. Favorite viruses include SARS-CoV-2 and influenza.
Recent work includes investigating the role of mutations observed in variants of concern affecting coronavirus nucleocapsid function. We are also focused on understanding how the Rab11 pathway is utilized by influenza A and influenza B viruses, including its role in entry (of H3N2 isolates) and its role in viral genome trafficking and reassortment.
We are also interested in understanding the molecular basis of cargo specificity in cargo transport, using the Rab11 pathway and influenza as model systems. Finally, we seek to understand whether the Rab11 pathway functions as a universal ‘highway’ to transport IAV vRNPs in all species, or whether it functions as a host range determinant for zoonotic viruses infecting human cells.
News
- Congrats to Matthew
Matthew won first place in the College round of the Three Minute Thesis Competition and went on to win the People’s Choice Award at the University level with his talk “Cellular Grand Theft Auto”, which he describes in a blog post here. The lab went out to celebrate! - ASV 2025
Allyson gave a talk on a new role for Rab11B in the entry of current H3N2 isolates, while Sara gave a flash talk and poster on the role of Rab25 in IAV infection! - Congrats to Sara
Sara defended her Accelerated Master’s Thesis on the role of Rab25 in influenza infection.
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